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The human body is composed of individual cells that require a continual amount of energy to carry out life functions. One of the body’s major systems, the digestive, is responsible for breaking down food into smaller nutrients, so they can be absorbed and used by cells. During digestion, foods containing carbohydrates (complex sugars) are broken down into simple sugars called glucose. These molecules are the smallest units of energy, ultimately broken down by cells in order to do work.
Broken down in the digestive system, glucose passes through the digestive tract until it reaches the small intestines, where it is is absorbed into the vascular system through a network of overlapping microscopic blood vessels. Through a process called diffusion, glucose molecules are transported through the permeable walls of the small intestines and taken into the bloodstream. Glucose circulates through the vascular system, eventually being pulled out of the bloodstream into tissues and cells. Within cells, glucose is broken down and its energy is released for the movement of muscles, functioning of organs, and carrying out of everyday life activities.
The Role of Insulin:
One important chemical required for the transport of glucose out of the bloodstream and into cells is insulin. Produced by the pancreas, insulin is released into the bloodstream where it acts as a "carrier", attaching itself to glucose and transporting the molecule through the walls of blood vessels, and into tissues and cells. If insulin is not present in the blood stream, molecules of glucose remain in blood, and create a condition called hyperglycemia, a state of increased sugar levels in the bloodstream. Type I and Type II diabetes are disorders where individuals either lack the production of insulin, or are not able to utilize insulin efficiently. In either case, individuals with these disorders are confronted with the condition of elevated blood sugar levels.
Type I diabetes is a genetic autoimmune disorder, where an individuals own immune system attacks the insulin producing beta-cells of the pancreas. As a result, Type I diabetics lack insulin producing beta cells, and are required to administer artificial insulin from a very early age, so that glucose obtained through meals can be transported out on the bloodstream and used efficiently by cells.
Type II diabetes is a much more common disorder, and results both from a genetic susceptibility and environmental factors. The disorder usually manifests later in life, and is due to "cellular resistance" to insulin, where cells become insensitive to using the chemical. Although Type II diabetics may even produce elevated levels of insulin to compensate for insulin resistance by cells, there is still a relative deficiency of insulin due to the inability to use insulin efficiently. Factors such as an uncontrolled diet and obesity contribute to Insulin resistance.
Osmosis; A Fundamental Principle:
Osmosis is the movement of water through a permeable membrane into a region of higher particle concentration, aiming to equalize the proportion of water and particle concentrations on the two sides. Movement of water goes from the less-concentrated (hypotonic) area of particles, to the more-concentrated (hypertonic) area, in an attempt to to reduce the difference in concentration between the two particle areas. Osmosis is essential in biological systems, since it provides the primary means by which water is transported in and out of the vascular system. It is a fundamental principle that the body uses in order to maintain homeostasis (equilibrium).
One of the primary functions of the vascular system is to distribute water (H2O) to cells, a substance necessary for their proper functioning. Normal glucose levels in the vascular system allow the appropriate amount of water to leave the bloodstream to enter tissues and cells, while maintaining appropriate blood pressure levels. However, excess glucose levels in the vascular system create oncotic pressure (colloid osmotic pressure), a force that pulls water away from tissues and cells back into the bloodstream.
In medical terms, elevated glucose levels in the bloodstream create hypertension, or increased blood pressure, a common characteristic of a diabetic individual who does not control blood sugar levels. Hypertension is common in individuals with elevated blood sugar levels since excess glucose particles attract water from tissues and cells back into the bloodstream. Osmosis, the movement of water to an area of higher particle concentration, is the body's fundamental response to dilute high concentrations of glucose levels in a diabetic patient.
It is important for diabetic patients to have a controlled diet including limited glucose intake, and regular insulin administration prior to meals so the chemical can transport glucose once it is in the bloodstream. Otherwise, consistent elevated glucose levels in diabetics can lead to chronic hypertension, which can lead to life altering diabetic disorders such as nephropathy, neuropathy, and retinopathy.
Macroscopic Disorders:
Nephropathy is a disorder caused by damage to nephrons, the basic filtration units of the kidney. Chronic high blood pressure causes an increased volume of blood to pass through the kidneys. Over time, the kidney's nephrons are mechanically damaged, eventually leading to a decline in their ability to filter the blood. This condition can lead to build-up of toxicity in blood, and escape of necessary nutrients of glucose and proteins into urine.
Microscopic Disorders:
Neuropathy and Retinopathy are disorders caused by damage to the microscopic blood vessels of the vascular system. High blood pressure makes nerves in the extremities and the retina especially susceptible to breaking down. Over time, a consistent high blood volume mechanically damages small blood vessels that carry oxygen and nutrients to those areas, causing nerves and retina to be injured. Loss of sensitivity in hands and feet, and loss of vision are common to patients with chronic diabetes.
Pedram Javaherian
pedram@literarytruth.com